A match each will be played in the English Premier League, Spanish La Liga, Italian Serie A, German Bundesliga, and the French Ligue 1 on Friday, November 5.
See fixtures and time (WAT) below:
20:00 Southampton vs Aston Villa
La Liga Satander
20:00 Athletic Bilbao vs Cadiz
Italian Serie A
19:45 Empoli vs Genoa
19:30Mainz vs Borussia Monchengladbach
20:00Lens vs Troyes
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