Barcelona will hope to bounce back against Rayo Vallecano after the disappointing loss at home to arch rivals, Real Madrid.
Real Madrid will also be in action at home against Osasuna.
See fixtures and time (WAT) below:
18:00 Mallorca vs Sevilla
18:00 Rayo Vallecano vs Barcelona
19:00 Real Betis vs Valencia
20:30 Real Madrid vs Osasuna